EXCEED™ MEDICAL MICRONEEDLING

Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects with Mild to Moderate Blemish-Prone Skin

Deanne Robinson, Daniel Friedmann, Jennifer Gordon, Mitchell Wortzman, Diane Nelson

Topical retinoids influence the rate of cellular turnover and improve skin clarity and photoaged skin. Consequent cutaneous irritation reduces adherence resulting in suboptimal outcomes. A formulation comprised of a double-conjugated molecule containing a retinoid and an alpha hydroxy acid (AHA) has been purposefully developed for individuals with blemish-prone skin.

Efficacy and Tolerability of Double-Conjugated Retinoid Cream vs. 1.0% Retinol Cream or 0.025% Tretinoin Cream in Subjects with Mild to Severe Photoaging

David H. McDaniel, Christopher Mazur, Mitchell S. Wortzman, Diane B. Nelson

Evaluate the effectiveness and tolerability of a double-conjugate retinoid cream (AlphaRet Overnight Cream; AHA-Ret) in improving visible signs of photoaging vs 1.0% retinol or 0.025% tretinoin.

A Comprehensive Topical Antioxidant Inhibits Oxidative Stress Induced by Blue Light Exposure and Cigarette Smoke in Human Tissue

Mitchell Wortzman, Diane B. Nelson

Skin damage from visible light predominantly results from exposure to the blue light spectrum (400-500 nm) which generates Reactive Oxygen Species (ROS) causing a cascade of harmful effects to skin. Topical antioxidants reduce the effects of free radical damage caused by environmental exposures. This study evaluated a comprehensive topical antioxidant's ability to inhibit ROS production induced by blue light and cigarette smoke (CS) in human skin.

Evaluation of the Antioxidant Capacity and Protective Effects of a Comprehensive Topical Antioxidant Containing Water-Soluble, Enzymatic, and Lipid-Soluble Antioxidants

David H. McDaniel, Jacob M. Waugh, Lily I. Jiang, Thomas J. Stephens, Alex Yaroshinsky, Chris Mazur, Mitchell Wortzman, Diane B. Nelson

Investigators sought to evaluate the antioxidant capacity of a comprehensive topical antioxidant (WEL-DS), its ability to protect skin against the oxidizing effects of UVA/UVB radiation, and to assess the effectiveness and tolerability of WEL-DS for visible improvements in facial photodamage.